News

Velabs Therapeutics receives exclusive licence from alytas therapeutics for the development of therapeutic antibodies as senolytics

Contact

Dr. Christoph Antz
Managing Director

Velabs Therapeutics GmbH

Meyerhofstrasse 1
69117 Heidelberg

+49 6221 3878194
antz@velabs-therapeutics.com

Velabs Therapeutics GmbH (Velabs), a biotech company focused on the rapid screening of functional therapeutic antibodies announced that it has entered into an exclusive licence agreement with alytas therapeutics GmbH (alytas), for the development and commercialization of alytas’ antibodies in the field of senescence, related degenerative processes and pathologies.

Velabs Therapeutics, a young start-up company of the European Molecular Biology Laboratory (EMBL), is a pioneer of microfluidic technology for the screening of antibodies with modulatory function on complex signalling proteins such as GPCRs, ion channels or other regulatory proteins. The current active investor is Xlife Sciences AG (m:access: XLS, www.xlifesciences.ch), a Swiss company focusing on the development of promising life science technologies. Velabs offers its screening know-how and capacities for pharmaceutical collaborations worldwide. In addition to existing partnerships, Velabs is currently building its own pipeline of therapeutic antibody candidates for further development. Recently, the company has started to develop antibody-based senolytics, a class of drugs designed to prevent cell and tissue degeneration that can occur during the aging process by eliminating so-called “senescent cells.”

alytas specializes in the research of fat metabolism in connection with obesity. Its program is based on several proprietary protein epitopes with high relevance for the immunological regulation of excess adipocytes and has already been conceptually confirmed in vitro and in vivo. In a previous strategic partnership, alytas and Velabs co-developed different sets of preclinical antibodies for a novel immune-based obesity treatment. The current licence will allow Velabs to exclusively develop these antibodies against senescence related degenerative processes. Both indications, obesity and senescence, together with their associated co-morbidities, are conditions with unmet medical need and enormous market potential.

Christoph Antz, Managing Director of Velabs, states:
“We are pleased to have entered this licence agreement with alytas, which will allow us to develop a completely new treatment against ageing related decline of body functions. We are confident that this new approach has the potential to open new ways towards less associated deteriorations, higher degrees of vitality and better health conditions during human ageing process, thus increasing quality of life at older age and reducing the burden of age-related diseases and complaints. Velabs’ know-how in the generation and preclinical validation of functional antibodies will be instrumental in developing a first mover antibody-based therapy for the preventive delay of senescence associated body decline.”

About Velabs Therapeutics

Therapeutics Velabs Therapeutics is a spin-out from Europe’s most prestigious life science research and instrumentation
institute, the European Molecular Biology Laboratory (EMBL), standing at the forefront of microfluidics-based screening technology and applications world-wide. The company’s droplet-based microfluidic screening technology aims at the fast generation of antibodies against target molecules presented on cellular membrane surfaces or as soluble protein. VELABS has pioneered the use of droplet microfluidics for the fast screening of correctly paired human antibodies that do not just bind to a drug target, but rather modulate its function.

For more information, please visit please visit

velabs.com

About alytas therapeutics

alytas therapeutics GmbH is a spin-off of the University of Jena with the aim to develop a therapeutic antibody for the treatment of morbid obesity. The Company, which is financed and managed by the Swiss-based Xlife Sciences Ltd., has know-how and patents on several antigenic epitopes with proven relevance to novel therapeutic immune-based regulation of excessive amounts of adipocytes in patients with obesity. The founders of alytas have been working for many years in the field of obesity and their current treatment hypothesis is based on in vitro and in vivo data from humans and animals. The company is set up as a Lean Project Management Engine with various core partnerships.

For more information, please visit

alytas.com

About Xlife Sciences AG

Xlife Sciences AG is a Swiss company with focus on investing in promising technologies in the life science industry. Xlife Sciences AG is building the bridge from research and development to healthcare markets by supporting researchers and entrepreneurs in positioning, structuring, developing and implementing their concepts. Together with industrial partners or universities, Xlife Sciences AG leads projects through the proof-of-concept phase after an invention disclosure or start-up. Subsequently, the firm focuses on out-licensing or selling the company, often with a combination of a strategic partnership. Xlife Sciences AG offers its investors direct access to the further development of innovative and future-oriented technologies at a very early stage.

For more information, please visit

xlifesciences.ch

07.01.2020

Velabs Therapeutics announces strategic partnership with alytas therapeutics to develop a novel immune-based therapy for obesity

Contact

Dr. Christoph Antz
Managing Director

Velabs Therapeutics GmbH

Meyerhofstrasse 1
69117 Heidelberg

+49 6221 3878194
antz@velabs-therapeutics.com

Velabs Therapeutics GmbH (Velabs), a biotech company focused on the rapid screening of functional therapeutic antibodies, today announces that it has entered into a partnership agreement with alytas therapeutics GmbH (alytas), to jointly develop modulatory and functional antibodies for a novel immune-based therapy against obesity. The collaboration will leverage Velabs’ proprietary microfluidic-based technology for rapid functional antibody screening. Velabs will be entitled to royalties from the worldwide sales of products that result from the collaboration.

Velabs Therapeutics is a pioneer in microfluidic technology for the screening of antibodies with modulatory function on complex signaling proteins. Its proprietary high-throughput screening platform makes it possible to test millions of correctly paired, fully natural human and mouse IgGs for therapeutic effects. Results are achieved in only a fraction of the time required by other technologies. The Company offers customized screening services for users worldwide. In addition to the execution of service projects, Velabs is currently building its own pipeline of therapeutic antibody candidates for further joint development with pharmaceutical partners.

Alytas specializes in the research of fat metabolism in connection with obesity, and has identified and validated target genes for the development of a novel immune-based obesity treatment. Its program is based on a number of proprietary protein epitopes with high relevance for the immunological regulation of excess adipocytes, and has already been conceptually confirmed in vitro and in vivo.

Christoph Antz, Managing Director of Velabs, said:
“We are pleased to have reached this partnership agreement with alytas, which will allow for the development of a completely new treatment option for obesity. The collaboration will benefit from our expertise in rapid screening and the generation of functional antibodies on complex signaling proteins. This knowledge will be instrumental in developing a first mover immunotherapy for obesity and can help to significantly reduce the global increase in associated co-morbidities such as diabetes and cardiovascular disease.”

About Velabs Therapeutics

Therapeutics Velabs Therapeutics is a spin-out from Europe’s most prestigious life science research and instrumentation
institute, the European Molecular Biology Laboratory (EMBL), standing at the forefront of microfluidics-based screening technology and applications world-wide. The company’s droplet-based microfluidic screening technology aims at the fast generation of antibodies against target molecules presented on cellular membrane surfaces or as soluble protein. VELABS has pioneered the use of droplet microfluidics for the fast screening of correctly paired human antibodies that do not just bind to a drug target, but rather modulate its function.

For more information, please visit please visit

velabs.com

About alytas therapeutics

alytas therapeutics GmbH is a spin-off of the University of Jena with the aim to develop a therapeutic antibody for the treatment of morbid obesity. The Company, which is financed and managed by the Swiss-based Xlife Sciences Ltd., has know-how and patents on several antigenic epitopes with proven relevance to novel therapeutic immune-based regulation of excessive amounts of adipocytes in patients with obesity. The founders of alytas have been working for many years in the field of obesity and their current treatment hypothesis is based on in vitro and in vivo data from humans and animals. The company is set up as a Lean Project Management Engine with various core partnerships.

For more information, please visit

alytas.com

03.09.2019

Velabs Therapeutics enters into a screening cooperation with Chiome Bioscience in the field of GPCR-specific functional antibody screening after successful feasibility study

Contact

Dr. Christoph Antz
Managing Director

Velabs Therapeutics GmbH

Meyerhofstrasse 1
69117 Heidelberg

+49 6221 3878194
antz@velabs-therapeutics.com

Velabs Therapeutics, specializing in the fast generation of functional therapeutic antibodies, today announced that its cooperation with Chiome Bioscience, Inc., Tokyo, will be deepened, to jointly discover modulatory and functional antibodies for one of Chiome’s GPCR target genes. The collaboration will capitalize on Velabs’ microfluidics-based technology in the field of functional antibody screening. Under the terms of the agreement and after successful completion of an initial feasibility phase, Velabs will receive milestone payments upon the achievement of specific development and regulatory events. In addition, Velabs will also be eligible to receive tiered royalties and milestones on the worldwide sales of products that arise from the collaboration.

Chiome Bioscience is a leading expert in the discovery and development of therapeutic antibodies for clinical applications with unmet medical need. The company has the exclusive license of the ADLib® antibody generation technology from RIKEN and has several preclinical and clinical development programs for its therapeutic antibodies.

Velabs Therapeutics, a recent startup company of the European Molecular Biology Laboratory (EMBL) and financed by Swiss based Xlife Sciences Ltd., is a pioneer in microfluidic technology for screening of antibodies with modulatory function on complex signal proteins like GPCRs or ion channels. The high-throughput screening platform allows for testing millions of correctly paired fully natural IgGs from humans and mice for therapeutic effects, rather than just for binding. Results are obtained in only a fraction of the time required by other technologies. The company offers customized screening services for users worldwide. Besides carrying out service projects, Velabs is currently also establishing its own proprietary pipeline of therapeutic antibody candidates for further joint development with pharma partners.

“We are delighted about the successful termination of the initial feasibility phase and the current start of a joint development on functional GPCR antibodies.”, says Christoph Antz, Managing Director of Velabs. “Chiome’s decision to continue this project after a successful feasibility study represents an important validation of our technology for the screening and generation of functional antibodies on complex signal proteins like GPCRs.” adds Christoph Merten, scientific founder and CSO of Velabs.

“We opted for Velabs’ microfluidic screening technology in order to optimize time and productivity of discovering therapeutic antibodies against GPCRs. We look forward to obtaining promising hits, which can ultimately give rise to preclinical candidates through this collaboration”, says Yukoh Nakazaki, Head of Antibody Research Laboratories of Chiome Bioscience.

About Velabs Therapeutics

Therapeutics Velabs Therapeutics is a spin-out from Europe’s most prestigious life science research and instrumentation
institute, the European Molecular Biology Laboratory (EMBL), standing at the forefront of microfluidics-based screening technology and applications world-wide. The company’s droplet-based microfluidic screening technology aims at the fast generation of antibodies against target molecules presented on cellular membrane surfaces or as soluble protein. VELABS has pioneered the use of droplet microfluidics for the fast screening of correctly paired human antibodies that do not just bind to a drug target, but rather modulate its function.

For more information, please visit please visit

velabs.com

About Chiome Bioscience

Chiome Bioscience is a clinical stage biotechnology company. Chiome’s focus is on discovery and development of antibody-based therapeutics in the disease areas with unmet medical needs. Currently it is advancing two programs in oncology. Chiome has proprietary antibody generating technology named ADLib® System and has several antibody discovery and preclinical programs. Chiome was founded in 2005, is listed in Tokyo stock exchange Mothers (code: 4583), and located in Tokyo, Japan.

For more information, please visit

chiome.co.jp

27.08.2019

Velabs Therapeutics Announces €3 Million Series B Financing to Advance its Functional Antibody Screening Programme

Contact

Dr. Christoph Antz
Managing Director

Velabs Therapeutics GmbH

Meyerhofstrasse 1
69117 Heidelberg

+49 6221 3878194
antz@velabs-therapeutics.com

Velabs Therapeutics GmbH, a leader in rapid screening of functional therapeutic antibodies, today announced the closing of a €3 million Series B financing round to advance its functional antibody screening programme and to strengthen its own pipeline of preclinical functional antibodies against diseases with poor treatment options. Further details of the financing round were not disclosed.

Velabs Therapeutics, a young spin-off company of the European Molecular Biology Laboratory (EMBL), is a pioneer of microfluidic technology for the screening of antibodies with modulatory function on complex signalling proteins such as GPCRs, ion channels or other regulatory signalling proteins. Its proprietary high-throughput screening platform makes it possible to test millions of correctly paired, fully natural human and mouse antibodies for their therapeutic effects, not just for binding. Results are achieved in only a fraction of the time required by other technologies. The company offers customized screening services for users worldwide. In addition to existing pharma co-development partnerships, Velabs is currently building its own pipeline of therapeutic antibody candidates for further joint development with interested partners.

“This investment will enable us to advance the development of our own pipeline of preclinical functional antibodies and secure the expansion of our platform technology into new pharma-based co-development deals,” said Christoph Antz, Managing Director of Velabs. “Further preclinical validation of our own antibody drug candidates against GPCRs and Ion Channels will enhance our position as a leader in the field of rapid functional antibody screening and development,” adds Christoph Merten, scientific founder and CSO of Velabs.

“We are glad to see Velabs Therapeutics growing into a leading company for fast antibody screening. This financing round will position Velabs as a prime partner for companies seeking rapid generation of functional antibody drug candidates on complex signal proteins,” says Jürgen Bauer, Deputy Managing Director of EMBL Enterprise Management Technology Transfer GmbH (EMBLEM).

About Velabs Therapeutics

Therapeutics Velabs Therapeutics is a spin-out from Europe’s most prestigious life science research and instrumentation
institute, the European Molecular Biology Laboratory (EMBL), standing at the forefront of microfluidics-based screening technology and applications world-wide. The company’s droplet-based microfluidic screening technology aims at the fast generation of antibodies against target molecules presented on cellular membrane surfaces or as soluble protein. VELABS has pioneered the use of droplet microfluidics for the fast screening of correctly paired human antibodies that do not just bind to a drug target, but rather modulate its function.

For more information, please visit please visit

velabs.com

27.06.2019

Velabs Therapeutics to cooperate with Chiome Bioscience in the field of GPCR-specific functional antibody screening

Contact

Dr. Christoph Antz
Managing Director

Velabs Therapeutics GmbH

Meyerhofstrasse 1
69117 Heidelberg

+49 6221 3878194
antz@velabs-therapeutics.com

Velabs Therapeutics, specializing in the fast generation of functional therapeutic antibodies, today announced that it has entered into an agreement with Chiome Bioscience, Inc., Tokyo, to jointly discover modulatory and functional antibodies for one of Chiome’s GPCR target genes. The collaboration will capitalize on Velabs’ microfluidics-based technology in the field of functional antibody screening. Under the terms of the agreement, Velabs will receive an upfront payment after a successful first feasibility study and milestone payments upon the achievement of specific development and regulatory events. In addition, Velabs will also be eligible to receive tiered royalties and milestones on the worldwide sales of products that arise from the collaboration.

Chiome Bioscience is a leading expert in the discovery and development of therapeutic antibodies for clinical applications with unmet medical need. The company has the exclusive license of the ADLib® antibody generation technology from RIKEN and has several preclinical and clinical development programs for its therapeutic antibodies.

Velabs Therapeutics, a recent startup company of the European Molecular Biology Laboratory (EMBL), is a pioneer in microfluidic technology for screening of antibodies with modulatory function on complex signal proteins like GPCRs or ion channels. The high-throughput screening platform allows for testing millions of correctly paired fully natural IgGs from humans and mice for therapeutic effects, rather than just for binding. Results are obtained in only a fraction of the time required by other technologies. The company offers customized screening services for users worldwide. Besides carrying out service projects, Velabs is currently also establishing its own proprietary pipeline of therapeutic antibody candidates for further joint development with pharma partners.

“This agreement represents an important deal for Velabs.”, says Christoph Antz, Managing Director of Velabs. “It combines for the first time Velabs capacities of screening and generation of functional antibodies on complex signal proteins like GPCRs with Chiome’s target specific know how for a fast and straightforward preclinical validation path” adds Christoph Merten, scientific founder and CSO of Velabs.

“We opted for Velabs’ microfluidic screening technology in order to optimize time and productivity of discovering therapeutic antibodies against GPCRs. We look forward to obtaining promising hits, which can ultimately give rise to preclinical candidates through this collaboration”, says Yukoh Nakazaki, Head of Antibody Research Laboratories of Chiome Bioscience.

About Velabs Therapeutics

Therapeutics Velabs Therapeutics is a spin-out from Europe’s most prestigious life science research and instrumentation
institute, the European Molecular Biology Laboratory (EMBL), standing at the forefront of microfluidics-based screening technology and applications world-wide. The company’s droplet-based microfluidic screening technology aims at the fast generation of antibodies against target molecules presented on cellular membrane surfaces or as soluble protein. VELABS has pioneered the use of droplet microfluidics for the fast screening of correctly paired human antibodies that do not just bind to a drug target, but rather modulate its function.

For more information, please visit please visit

velabs.com

About Chiome Bioscience

Chiome Bioscience is a clinical stage biotechnology company. Chiome’s focus is on discovery and development of antibody-based therapeutics in the disease areas with unmet medical needs. Currently it is advancing two programs in oncology. Chiome has proprietary antibody generating technology named ADLib® System and has several antibody discovery and preclinical programs. Chiome was founded in 2005, is listed in Tokyo stock exchange Mothers (code: 4583), and located in Tokyo, Japan.

For more information, please visit

chiome.co.jp

24.04.2019

Velabs Therapeutics to cooperate with BioMed X in the field of immunology

Contact

Dr. Christoph Antz
Managing Director

Velabs Therapeutics GmbH

Meyerhofstrasse 1
69117 Heidelberg

+49 6221 3878194
antz@velabs-therapeutics.com

Velabs Therapeutics, specializing in the fast generation of functional therapeutic antibodies, today announced that it has entered into a collaboration agreement with BioMed X Innovation Center, Heidelberg. The collaboration will capitalize on Velabs’ microfluidics-based technology in the field of T-cell screening.

The BioMed X Innovation Center is a new collaboration model at the interface between academia and industry. BioMed X is using the Velabs platform to support the research team of John Lindner to explore new concepts for rapid identification of auto-antigens in autoimmune diseases. The research team, sponsored by Janssen Research & Development, LLC, will use high-throughput microfluidic screening approaches to couple T-cell receptor specificity with auto-antigens.

Velabs Therapeutics, a recent startup company of the European Molecular Biology Laboratory (EMBL), is a pioneer in microfluidic technology for functional screening of antibodies and single immune cells. The high-throughput screening platform allows for testing millions of correctly paired fully natural IgGs from humans and mice for therapeutic effects, rather than just for binding. Results are obtained in only a fraction of the time required by other technologies. The company offers customized screening services for users worldwide. Besides carrying out service projects, Velabs is currently also establishing its own proprietary pipeline of therapeutic antibody candidates for further joint development with pharma partners.

“We are excited by this new cooperation with one of BioMed X’s top research teams.”, says Christoph Antz, Managing Director of Velabs. “The company’s capacities in fast screening of single cells and functional antibodies will strongly support a superior performance of BioMed X’s research team.”, adds Christoph Merten, scientific founder and CSO of Velabs.

“In order to address the central challenge of screening and characterizing different immune cells at large scale, the research team chose Velabs’ technology as the most suitable and promising microfluidic screening platform available”, says Christian Tidona, founder and Managing Director of BioMed X.

About Velabs Therapeutics

Therapeutics Velabs Therapeutics is a spin-out from Europe’s most prestigious life science research and instrumentation
institute, the European Molecular Biology Laboratory (EMBL), standing at the forefront of microfluidics-based screening technology and applications world-wide. The company’s droplet-based microfluidic screening technology aims at the fast generation of antibodies against target molecules presented on cellular membrane surfaces or as soluble protein. VELABS has pioneered the use of droplet microfluidics for the fast screening of correctly paired human antibodies that do not just bind to a drug target, but rather modulate its function.

For more information, please visit please visit

velabs.com

About BioMed X

The BioMed X Innovation Center is an exciting new collaboration model at the interface between academia and industry. At the center, distinguished early career scientists recruited from all over the world jointly work on novel pre-clinical research projects in the fields of biomedicine, molecular biology, cell biology, diagnostics and consumer care. These interdisciplinary project teams conduct groundbreaking biomedical research in an open innovation lab facility at the Technology Park on the campus of the University of Heidelberg, Germany. They are working under the guidance of experienced mentors from academia and industry while expanding their scientific network and receiving entrepreneurship and leadership training. Each team is typically sponsored by a corporate pharma partner of BioMed X. After a fully funded project term, successful projects are either internalized into the development pipeline of the respective pharma partner or transformed into an independent start-up company. BioMed X collaborates with pharma companies such as AbbVie, Boehringer Ingelheim, Janssen, Merck and Roche.

For more information, please visit

bio.mx

07.01.2019

New EMBL spinoff company Velabs Therapeutics strives to speed up the discovery of new and better therapeutic antibodies

Contact EMBLEM:

Annabelle Grimm
EMBLEM Technology Transfer GmbH

Boxbergring 107
69126 Heidelberg

+49-6221-363-22-24
grimm@embl.de

An established proprietary microfluidics technology from the European Molecular Biology Laboratory (EMBL) allows for fast screening of antibodies from natural sources and even difficult targets. With the startup company Velabs Therapeutics, launched by EMBL and its technology transfer arm EMBLEM Technology Transfer GmbH (EMBLEM) together with private investors, the advantages of the platform are now made accessible to the antibody community around the globe.

“We have been using microfluidics at EMBL for years, and seen its potential in different fields”, says Christoph Merten, group leader at EMBL Heidelberg and developer of the platform. “Especially in the field of antibody-screening the advantages of our platform over existing technologies stood out.”

Velabs is a pioneer in microfluidics-based technologies for functional screening of antibodies. The high-throughput screening platform allows for testing millions of correctly paired fully natural IgGs from humans and mice for therapeutic effects, rather than just for binding. Results are obtained in only a fraction of the time required by other technologies. Velabs’ antibody screens can thus significantly and competitively shorten pre-clinical development.

“We have built a solid patent portfolio around the microfluidic technology at EMBL over the years and the novel platform has been validated in several industry collaborations. Velabs Therapeutics now has a strong basis to expand the technology and make it broadly available in the market”, says Gábor Lamm, Managing Director for EMBLEM.

Velabs offers customized screening services for users worldwide. Besides carrying out service projects, the company also works on establishing a proprietary pipeline of therapeutic antibody candidates and further development of the technology platform.

About Velabs Therapeutics

Velabs Therapeutics is a spin-out from Europe’s most prestigious life science research and instrumentation institute, the European Molecular Biology Laboratory (EMBL), which has been at the forefront of microfluidics-based screening technology development and applications world-wide. The company’s droplet-based microfluidic screening technology aims at the fast generation of antibodies against target molecules presented on cellular membrane surfaces or as soluble protein. VELABS has pioneered the use of droplet microfluidics for the fast screening of correctly paired human antibodies that do not just bind to a drug target, but rather modulate its function.

For more information, please visit please visit

velabs.com

About EMBL

EMBL is Europe’s flagship laboratory for the life sciences. We are an intergovernmental organisation established in 1974 and are supported by over 20 member states. EMBL performs fundamental research in molecular biology, studying the story of life. We offer services to the scientific community; train the next generation of scientists and strive to integrate the life sciences across Europe. We are international, innovative and interdisciplinary. We are more than 1600 people, from over 80 countries, operating across six sites in Grenoble (France), Hamburg (Germany), Heidelberg (Germany), Cambridge (UK), Rome (Italy), and Barcelona (Spain). Our scientists work in independent groups and conduct research and offer services in all areas of molecular biology. Our research drives the development of new technology and methods in the life sciences. We work to transfer this knowledge for the benefit of society.

For more information, please visit

embl.de

About EMBLEM

EMBLEM, established in 1999, identifies, protects and commercializes the intellectual property developed in the EMBL world, from EMBL alumni and from non-EMBL third parties. EMBLEM currently manages a portfolio of more than 350 granted patents and patent applications, and has created 18 spin-out companies. EMBLEM facilitates and accelerates the transfer of innovative technology from basic research to industry by working closely with industrial partners spanning the biotech, IT and mechanical/electrical engineering markets and currently has more than 400 licensees of EMBL technologies.

For more information, please visit

embl-em.de

07.03.2018

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